COVID-19 pandemic increased ESKAPEEc bloodstream infections and amplified carbapenem resistance in Chinese children: a multicenter surveillance study (2016–2023)
The incidence of ESKAPEEc in BSIs has increased, and the rising resistance to imipenem and meropenem in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> underscores the need for continued surveillance. Carbapenems remain effective against Gram-negative ESKAPEEc, while vancomycin and linezolid remain effective against Gram-positive ESKAPEEc. Age-stratified strategies are essential to manage carbapenem-resistant <i>Klebsiella pneumoniae</i> in neonatal BSIs and carbapenem-resistant <i>Acinetobacter baumannii</i> in pediatric BSIs. The MIC values for vancomycin in MRSA strains remained stable over time, whereas a decreasing susceptibility trend to vancomycin in MSSA strains and linezolid MIC shifts were not observed. Our findings are expected to provide to treatment of bloodstream infections in children and evidence on best practices and resource sharing for policy consideration to healthcare providers at the local and international levels.
Authors
- Huijun Cai
- Hong Zhang (ORCID: https://orcid.org/0000-0002-0886-9531)
- Shifu Wang (ORCID: https://orcid.org/0000-0002-2131-9518)
- Jikui Deng (ORCID: https://orcid.org/0000-0002-0040-1491)
- Chunmei Jing (ORCID: https://orcid.org/0009-0005-9930-3582)
- Cai Wang
- Yinghu Chen (ORCID: https://orcid.org/0000-0001-8022-9478)
- Pan Fu (ORCID: https://orcid.org/0000-0003-2587-4348)
- Hongmei Xu (ORCID: https://orcid.org/0000-0002-8650-8694)
- Chunzhen Hua
- Chuanqing Wang (ORCID: https://orcid.org/0000-0002-0158-9094)
- Xiaoqiang Li (ORCID: https://orcid.org/0000-0001-9939-9901)
- Hui Yu (ORCID: https://orcid.org/0000-0002-6559-6111)
- Jianhua Hao (ORCID: https://orcid.org/0009-0007-0032-7221)
- Qing Cao
- Yuyang Zhou (ORCID: https://orcid.org/0009-0004-1255-557X)
- Jiaying Wu (ORCID: https://orcid.org/0000-0003-1317-001X)
- Mingming Zhou (ORCID: https://orcid.org/0009-0005-4493-8513)
- Huiling Deng (ORCID: https://orcid.org/0009-0003-1850-2690)
- Ruiqiu Zhao (ORCID: https://orcid.org/0000-0002-8041-9236)
- Yiping Chen
- Ting Zhang (ORCID: https://orcid.org/0009-0008-5670-9955)
Institutions
- Wenzhou Medical University (CN)
- China International Science and Technology Cooperation (CN)
- Shanghai Children's Medical Center (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Children's Hospital of Zhejiang University (CN)
- National Clinical Research (US)
- Kaifeng City Children's Hospital (CN)
- Xi’an Children’s Hospital (CN)
- Shenzhen Children's Hospital (CN)
- Children's Hospital of Fudan University (CN)
- Shanghai Children's Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Qilu Hospital of Shandong University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fcimb.2025.1685606
- Citations
- 3
- Primary Topic
- Antibiotic Use and Resistance
- Type
- article
- Field-Weighted Citation Impact
- 3.79