A novel methodological approach to understanding the cortical and subcortical effects of aerobic exercise in Parkinson’s disease
While exercise positively affects symptoms of PD, the precise effects of exercise on network activity remain unclear. The methods utilized for collecting and analyzing neural (cortical and subcortical) and exercise-related data during a typical bout of aerobic exercise suggest that this approach can be adopted for larger, long-term exercise studies in patients with PD and deep brain stimulation (DBS). The described protocol provides a roadmap for future projects aiming to combine STN-LFP and cortical data to better understand how exercise may alter cortico-basal-ganglia-thalamic dynamics in PD.
Authors
- Sara Davidson (ORCID: https://orcid.org/0000-0002-6019-3639)
- Visar Berki (ORCID: https://orcid.org/0000-0001-6311-2120)
- Jay L. Alberts (ORCID: https://orcid.org/0000-0002-9379-3630)
- Nitesh Singh Malan (ORCID: https://orcid.org/0000-0002-1581-7588)
- James Liao (ORCID: https://orcid.org/0000-0001-6605-9855)
- Anson B. Rosenfeldt (ORCID: https://orcid.org/0000-0001-5468-8208)
- Sean J. Nagel (ORCID: https://orcid.org/0000-0002-8886-7965)
- Benjamin L. Walter (ORCID: https://orcid.org/0000-0002-8323-6873)
- Mandy Miller Koop (ORCID: https://orcid.org/0000-0003-3047-8091)
- Andrew S. Bazyk
Institutions
- Cleveland Clinic (US)
- The Neurological Institute (US)
Publication Details
- Journal
- Frontiers in Human Neuroscience
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fnhum.2025.1657049
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense