Ultrastructure of human platelet concentrates after treatment with pathogen reduction technologies for prolonged storage
Platelet mitochondrial volume shrinks and canalicular system swells within the first 24 h after collection and then both remain rather constant for up to seven days with or without PRT treatment. Pathogen reduction technology - both INTERCEPT and MIRASOL - does not increase morphological platelet storage lesion.
Authors
- Mohammed Barham
- Birgit Gathof (ORCID: https://orcid.org/0000-0001-6336-3640)
- Wolfram F. Neiss (ORCID: https://orcid.org/0000-0002-5035-5825)
- Andrea Grandoch
- Susanne M. Picker
- Tobias Odenthal
Institutions
- University Hospital Cologne (DE)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fmed.2025.1682909
- Primary Topic
- Blood transfusion and management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Universitätsklinikum Köln