Evaluating the rational use of antidepressant in older patients: a comprehensive analysis of its association with cognitive impairment
Despite their widespread use, antidepressants raise concerns regarding their efficacy and safety, particularly due to the risk of exacerbating CI. This study underscores the need for careful management of antidepressant therapy and suggests exploring alternatives such as vortioxetine, which may offer cognitive benefits. Enhanced interprofessional collaboration and regular cognitive evaluations are recommended to improve patient outcomes and ensure the rational use of antidepressants.
Authors
- Lucrecia Moreno (ORCID: https://orcid.org/0000-0002-9456-9649)
- José Sendra‐Lillo (ORCID: https://orcid.org/0000-0002-2669-5862)
- Juan Pardo (ORCID: https://orcid.org/0000-0003-4184-9855)
- María Gil‐Peinado (ORCID: https://orcid.org/0000-0001-5593-1484)
- Mar García-Zamora (ORCID: https://orcid.org/0009-0004-4952-0258)
- Gonzalo Miguel Adsuar-Meseguer
Institutions
- Universitat de València (ES)
- Universidad Cardenal Herrera CEU (ES)
- Valencia Catholic University Saint Vincent Martyr (ES)
- Instituto de Investigación Sanitaria La Fe (ES)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fpsyt.2025.1624989
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00