Danggui Shaoyao San attenuates depressive-like behaviors in mice via TLR4/NF-κB p65/JAK-STAT3/AKT-GSK3β signaling pathways: modulation of hippocampal neurogenesis and neuroinflammation
Collectively, our study deciphers the anti-depressant mechanisms of DSS via TLR4/NF-κB p65, JAK2/STAT3 and AKT-GSK3β signaling pathways, while establishing a drug development paradigm that bridges ethnopharmacology and modern systems biology. This integration offers a blueprint for exploiting traditional medicines in CNS drug discovery.
Authors
- Qiaona Wang
- Yujie Zhu (ORCID: https://orcid.org/0000-0002-1414-2590)
- Fan Li (ORCID: https://orcid.org/0000-0002-4232-2492)
- Lijie Ma (ORCID: https://orcid.org/0000-0001-8584-3370)
- Junjie Shi (ORCID: https://orcid.org/0009-0008-9568-4914)
- Chuanfeng Tang (ORCID: https://orcid.org/0000-0001-9811-8450)
- Lang Xiang
- Pengfei Xie (ORCID: https://orcid.org/0000-0002-4143-0993)
- Jianmei Li (ORCID: https://orcid.org/0000-0001-7813-3047)
- Yizhu Zhang (ORCID: https://orcid.org/0000-0003-0494-0035)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Shengjie Li
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Normal University (CN)
- Nanjing Xiaozhuang University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fnut.2025.1652968
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68