Dopaminergic Degeneration Differentially Modulates Primary Motor Cortex Activity and Motor Behavior in Hemiparkinsonian Rats
M1 neuronal activity appears to be differentially modulated by dopaminergic degeneration and levodopa treatment in a lesion-dependent manner. These preliminary findings suggest dynamic cortical responses in PD and support the utility of calcium imaging for monitoring circuit-level changes in disease and therapy. Further research with larger cohorts and complementary methodologies will be necessary to validate and extend these observations.
Authors
- Suelen L. Boschen (ORCID: https://orcid.org/0000-0002-7694-920X)
- Rickey E. Carter (ORCID: https://orcid.org/0000-0002-0818-273X)
- J. Luis Luján (ORCID: https://orcid.org/0000-0003-3496-3932)
- Jodi L. Silvernail
- Minerva M. Carrasquillo (ORCID: https://orcid.org/0000-0002-3231-9134)
- Su-Youne Chang (ORCID: https://orcid.org/0000-0001-8373-8921)
- Launia J. White (ORCID: https://orcid.org/0000-0003-0251-9431)
- Wendy D. Lujan
- Julian Seethaler
- Shaohua Wang (ORCID: https://orcid.org/0000-0002-5553-2616)
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- National Institute of Environmental Health Sciences (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Brain Sciences
- Published
- 2025-10-18
- DOI
- https://doi.org/10.3390/brainsci15101123
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00