Cardiovascular-kidney-metabolic progression associated with major adverse liver outcomes: mediating roles of plasma metabolites
CKM progression elevates MALO risk, partially mediated by amino acids and fatty acids. These findings identify high-risk patients who may benefit from targeted liver surveillance for secondary prevention of CKM syndrome.
Authors
- Mengchen Zou (ORCID: https://orcid.org/0000-0003-1409-4645)
- Jingjing Liang (ORCID: https://orcid.org/0000-0002-4991-6517)
- Linna Li (ORCID: https://orcid.org/0000-0002-3241-3243)
- Shuxian Li (ORCID: https://orcid.org/0000-0002-2150-7404)
- Xianbo Wu (ORCID: https://orcid.org/0000-0002-2706-9599)
- Yilan Tan
- Lu He (ORCID: https://orcid.org/0000-0001-6207-1996)
- Yajun Xu (ORCID: https://orcid.org/0000-0002-4093-601X)
- Yongqi Liang (ORCID: https://orcid.org/0000-0001-7304-5144)
- Liwen Chen (ORCID: https://orcid.org/0000-0003-4705-4754)
- Mengyi Cai
Institutions
- Nanfang Hospital (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
- Jiangmen Central Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fnut.2025.1675899
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southern Medical University
- Nanfang Hospital