Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD
In this study involving 38 participants with geographic atrophy due to AMD, the PRIMA system restored central vision and led to a significant improvement in visual acuity from baseline to month 12. (Funded by Science Corporation and the Moorfields National Institute for Health and Care Research Biomedical Research Centre; PRIMAvera ClinicalTrials.gov number, NCT04676854.).
Authors
- Marco Pileri
- Karl Ulrich Bartz‐Schmidt (ORCID: https://orcid.org/0000-0001-8031-7478)
- Lars‐Olof Hattenbach (ORCID: https://orcid.org/0000-0002-5275-8118)
- Peter Szurman (ORCID: https://orcid.org/0000-0002-9636-7346)
- Frank Gerhard Holz (ORCID: https://orcid.org/0000-0001-8019-9272)
- Jean‐François Girmens (ORCID: https://orcid.org/0000-0002-9102-8716)
- Ralf Hornig
- Nicole Eter (ORCID: https://orcid.org/0000-0001-5617-346X)
- Koen A. van Overdam (ORCID: https://orcid.org/0000-0002-5425-7210)
- F. Matonti (ORCID: https://orcid.org/0000-0002-6180-3937)
- Lisa C. Olmos de Koo (ORCID: https://orcid.org/0000-0002-8146-4653)
- Wolf Armin
- Marie‐Noëlle Delyfer (ORCID: https://orcid.org/0000-0002-3127-8617)
- José‐Alain Sahel (ORCID: https://orcid.org/0000-0002-4831-1153)
- Boris V. Stanzel (ORCID: https://orcid.org/0000-0002-4316-1539)
- Daniel Palanker (ORCID: https://orcid.org/0000-0002-0480-3025)
- Y. Le Mer (ORCID: https://orcid.org/0000-0002-6925-3941)
- Frank Brodie (ORCID: https://orcid.org/0000-0002-6908-6557)
- Mahiul M. K. Muqit (ORCID: https://orcid.org/0000-0003-1161-3956)
- S. Grisanti (ORCID: https://orcid.org/0009-0003-9658-0926)
- Michel Weber
- Laurent Kodjikian
- Eric Souied
- Andrea Cusumano
- Martina Corazzol
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University of Rome Tor Vergata (IT)
- Centre National de la Recherche Scientifique (FR)
- Institut de la Vision (FR)
- University of Bonn (DE)
- Inserm (FR)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Universität Ulm (DE)
- University of Washington (US)
- Aix-Marseille Université (FR)
- University of Münster (DE)
- Azienda Ospedaliera San Giovanni Addolorata (IT)
- Centre hospitalier national d'ophtalmologie des Quinze-Vingts (FR)
- Erasmus MC (NL)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Sorbonne Université (FR)
- Centre National pour la Recherche Scientifique et Technique (CNRST) (MA)
- Hôpital de la Croix-Rousse (FR)
- Hôpital Rothschild (FR)
- Alameda Applied Sciences Corporation (United States) (US)
- Knappschaftsklinikum Saar (DE)
- Universitäres Kinderwunschzentrum Lübeck (DE)
- Hospices Civils de Lyon (FR)
- Clinical Research Organization (BD)
- Fondation de Rothschild (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Combined Ophthalmic Research Rotterdam (NL)
- Institute of Ophthalmology (MX)
- Institut de Neurosciences de la Timone (FR)
- STZ eyetrial (DE)
- Moorfields Eye Hospital (GB)
- Hôpital Intercommunal de Créteil (FR)
- Czech Academy of Sciences, Biology Centre (CZ)
- Laboratoire Médiations (FR)
- University College London (GB)
- University of Lübeck (DE)
- Stanford University (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1056/nejmoa2501396
- Citations
- 9
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 8.18