Chemotherapy Drug-induced Neurotoxicity: A Pharmacogenomic Perspective
Abstract: Chemotherapy remains the cornerstone of cancer treatment, significantly improving patient survival. However, chemotherapy is often accompanied by side effects that can have a negative impact on quality of life, with neurotoxicity being one of the most debilitating yet often overlooked complications. This study aims to explore the influence of genetic variations on chemotherapy-induced neurotoxicity. Utilizing the PharmGKB database, we identified genetic variants associated with neurotoxic responses and assessed their Level of Evidence (LOE). Our findings highlight several genes, BCL2, OPRM1, SOX10, TRPV1, CYP3A4*22, GSK3β, DPYD, and ADORA2A, that are involved in neurotoxicity induced by chemotherapeutic agents, such as platinum/taxane, vincristine, fluorouracil, and methotrexate. These genetic factors modulate individual susceptibility to neurotoxic side effects. Understanding these associations supports the development of genotype-guided therapeutic strategies to reduce toxicity and improve quality of life in cancer patients receiving chemotherapy.
Authors
- Amelia Nur Vidyanti (ORCID: https://orcid.org/0000-0002-2741-2983)
- Lalu Muhammad Irham (ORCID: https://orcid.org/0000-0002-0091-4887)
- Muhammad Reza Mahendra (ORCID: https://orcid.org/0009-0002-9754-1198)
- Wirawan Adikusuma (ORCID: https://orcid.org/0000-0001-9165-690X)
- Anisa Devi Kharisma Wibowo (ORCID: https://orcid.org/0009-0000-9196-7943)
- Maulida Mazaya (ORCID: https://orcid.org/0000-0003-2197-8449)
- İlker Ateş (ORCID: https://orcid.org/0000-0001-5791-7694)
- Rockie Chong (ORCID: https://orcid.org/0000-0001-6736-9687)
- Darmawi Darmawi (ORCID: https://orcid.org/0000-0002-5579-1749)
- Danang Prasetyaning Amukti (ORCID: https://orcid.org/0000-0002-4256-6534)
- Rina mutiara (ORCID: https://orcid.org/0000-0002-1051-0325)
Institutions
- Ankara University (TR)
- University of California, Los Angeles (US)
- Universitas Gadjah Mada (ID)
- Universitas Ahmad Dahlan (ID)
- University of Muhammadiyah Mataram (ID)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- Universitas Muhammadiyah Semarang (ID)
- National Research and Innovation Agency (ID)
- Riau University (ID)
Publication Details
- Journal
- Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine
- Published
- 2025-10-15
- DOI
- https://doi.org/10.2174/0118756921374917251002055229
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00