A Population Pharmacokinetics Model of Busulfan in Pediatric Patients with Thalassemia Major
The present study developed the first PPK model characterizing the pharmacokinetics of Bu specifically in children with thalassemia major. This study's final PPK model demonstrated that BSA was the key predictive covariate for CL and V.
Authors
- Dongwei Cui
- Qiru Su (ORCID: https://orcid.org/0000-0002-2598-9738)
- Fang Yao (ORCID: https://orcid.org/0000-0002-8562-6373)
- Xuejuan Li (ORCID: https://orcid.org/0000-0003-4086-6063)
- Sixi Liu
- Shijian Xiang (ORCID: https://orcid.org/0000-0002-7119-5728)
- Xiaoqin Feng (ORCID: https://orcid.org/0000-0003-1166-0138)
- Zebin Chen (ORCID: https://orcid.org/0000-0003-0054-3665)
- Fangyuan Lai
- Yue Li (ORCID: https://orcid.org/0000-0002-6908-3591)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Shenzhen Children's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Current Drug Metabolism
- Published
- 2025-10-20
- DOI
- https://doi.org/10.2174/0113892002402673251003055700
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00