Metabolic Perturbations and Ectopic Fat Deposition in Men With Low Birth Weight: Effects of a 4-Week Carbohydrate Overfeeding Challenge
Individuals with low birth weight (LBW) are at increased risk of type 2 diabetes. Four weeks of carbohydrate overfeeding (COF) was associated with differential elevations in fasting glucose, lipids, alanine, insulin resistance, and resting energy expenditure in LBW participants versus control participants. Multiomics analyses indicated reduced peroxisome proliferator-activated receptor signaling, as well as differential expression of genes involved in collagen and extracellular matrix metabolism in LBW participants during COF. Interestingly, the COF perturbations in LBW participants became more pronounced when excluding five LBW men with screen-detected metabolic dysfunction-associated steatotic liver disease. The findings support the notion of unhealthy subcutaneous adipose tissue expandability potentially underlying a reduced metabolic buffering capacity in nonobese LBW men.
Authors
- Gerrit van Hall (ORCID: https://orcid.org/0000-0002-2519-8127)
- Anne Cathrine B. Thuesen (ORCID: https://orcid.org/0000-0002-8639-9117)
- Rashmi B. Prasad (ORCID: https://orcid.org/0000-0002-4400-6741)
- Lauren Marie Sparks (ORCID: https://orcid.org/0000-0002-8724-6016)
- Mathias Ried‐Larsen (ORCID: https://orcid.org/0000-0002-8388-5291)
- Line O. Elingaard-Larsen (ORCID: https://orcid.org/0000-0001-9757-8383)
- Sofie Olund Villumsen (ORCID: https://orcid.org/0000-0002-9096-1555)
- Louise Justesen (ORCID: https://orcid.org/0000-0001-9362-3837)
- Leonie Mieke Engelhard (ORCID: https://orcid.org/0009-0008-9496-1297)
- Allan Vaag (ORCID: https://orcid.org/0000-0002-3690-2191)
- Natalia López‐Andrés (ORCID: https://orcid.org/0000-0003-3728-2606)
- Charlotte Brøns (ORCID: https://orcid.org/0000-0002-6653-9020)
- Torben Hansen (ORCID: https://orcid.org/0000-0001-8748-3831)
- Else Rubæk Danielsen
- Sidsel Seide Gertsen
Institutions
- Steno Diabetes Centers (DK)
- University of Southern Denmark (DK)
- Lund University (SE)
- Novo Nordisk Foundation (DK)
- Copenhagen University Hospital (DK)
- Navarrabiomed (ES)
- Translational Research Institute for Metabolism and Diabetes (US)
- Skåne University Hospital (SE)
Publication Details
- Journal
- Diabetes
- Published
- 2025-10-20
- DOI
- https://doi.org/10.2337/db25-0307
- Citations
- 1
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49