Integrated morphological, proteomic and metabolomic analyses reveal response mechanisms of microalgae under uranium exposure
Our findings demonstrate that <i>Ulothrix</i> sp. mitigates U-induced stress and maintains cellular homeostasis through a multi-level defense network. This network encompasses the activation of antioxidant enzymes, remodeling of key tricarboxylic acid (TCA) cycle metabolites, and strategic regulation of the glycine-serine-threonine metabolic pathway. This study provides crucial insights into the molecular and physiological basis of U tolerance in microalgae.
Authors
- Yang Xu (ORCID: https://orcid.org/0000-0001-7172-5277)
- Hailing Xi
- Bin Dong (ORCID: https://orcid.org/0000-0002-3196-0712)
- Jin-long Lai (ORCID: https://orcid.org/0000-0002-5542-3559)
- Sanping Zhao (ORCID: https://orcid.org/0000-0001-8124-2914)
- Mengwei Han
Institutions
- Southwest University of Science and Technology (CN)
- National Institute for Radiological Protection (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fmicb.2025.1679056
- Citations
- 2
- Primary Topic
- Radioactive element chemistry and processing
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- National Natural Science Foundation of China