The Schizosaccharomyces pombe Glycosyltransferase Gmh5 is a Functional Homologue of the α-1,6-Mannosyltransferase Mnn10 Crucial for N-Glycan Processing
This study provides the first functional characterization of Gmh5p as a mannosyltransferase of the GT34 family and demonstrates its role in N-glycan biosynthesis. Our findings expand the current understanding of the diversity and specificity of glycosyltransferases in eukaryotes and highlight their importance in cell wall biology.
Authors
- Sabine Strahl (ORCID: https://orcid.org/0000-0002-4024-0741)
- Mark Lommel (ORCID: https://orcid.org/0000-0001-6954-3714)
- Antonija Grbavac (ORCID: https://orcid.org/0000-0003-2614-2739)
- Irmgard Sinning (ORCID: https://orcid.org/0000-0001-9127-4477)
- Lina Šiukštaitė (ORCID: https://orcid.org/0000-0002-0899-1916)
- Franziska Hutzler
- Klemens Wild (ORCID: https://orcid.org/0000-0001-9733-8187)
Institutions
- Heidelberg University (DE)
Publication Details
- Journal
- Food Technology and Biotechnology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.17113/ftb.64.01.26.9195
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft