Formononetin mitigates alcoholic liver disease by restoring ALDH2 function and inducing ERK1/2–Nrf2 antioxidant signaling
FN ameliorated alcohol-induced liver damage by directly targeting ALDH2 to promote acetaldehyde detoxification and indirectly activating the ALDH2-ERK1/2-Nrf2 axis to enhance antioxidant capacity. FN might serve as a promising therapeutic candidate for the treatment of ALD.
Authors
- Aidong Wen (ORCID: https://orcid.org/0000-0002-4535-0501)
- Zhongying Ma (ORCID: https://orcid.org/0000-0002-5202-9775)
- Jin Sun (ORCID: https://orcid.org/0000-0001-8525-8796)
- Chao Guo (ORCID: https://orcid.org/0000-0003-2259-0788)
- Jingwen Wang (ORCID: https://orcid.org/0000-0003-1777-5307)
- Yi Qiao (ORCID: https://orcid.org/0000-0001-7032-1385)
- Lun Zhou
- Jia Ju (ORCID: https://orcid.org/0000-0002-0359-9261)
- Qianwen Wu (ORCID: https://orcid.org/0000-0002-7475-3457)
- Qian Ren (ORCID: https://orcid.org/0000-0003-3113-2156)
- Jing Niu (ORCID: https://orcid.org/0009-0009-2048-662X)
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1016/j.phymed.2025.157408
- Citations
- 3
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 4.41