Generation and characterization of a mouse model for bile salt export pump deficiency with the p.E297G mutation
BSEP<sup>E297G</sup> mice display a BSEP deficiency phenotype with a strongly reduced hepatobiliary bile acid transport capacity. The expression of immature BSEP protein suggests the potential to assess correctors of the BSEP functionality in vivo.
Authors
- Nicolette Huijkman
- Martijn Koehorst (ORCID: https://orcid.org/0000-0001-6219-0901)
- Bart van de Sluis (ORCID: https://orcid.org/0000-0003-3039-4365)
- Henkjan J. Verkade (ORCID: https://orcid.org/0000-0002-7034-2861)
- Folkert Kuipers (ORCID: https://orcid.org/0000-0003-2518-737X)
- Antonia Felzen (ORCID: https://orcid.org/0000-0003-0326-9622)
- Milaine V. Hovingh
- Willemien F. J. Hof (ORCID: https://orcid.org/0009-0002-3345-9785)
- H. de Vries (ORCID: https://orcid.org/0000-0002-1713-1002)
- Niels Kloosterhuis (ORCID: https://orcid.org/0009-0000-5500-3282)
- Jan Freark de Boer (ORCID: https://orcid.org/0000-0001-6759-3291)
- Niels L. Mulder
- Rick Havinga
- Marieke Smit
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.bbalip.2025.159697
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00