Targeted Delivery of Triptolide Alleviates Diabetic Nephropathy via Inactivation of JAK2-STAT1 Signaling.
TP improves renal inflammation, fibrosis, apoptosis, and lipid homeostasis, thereby ameliorating DN by inhibiting JAK2-STAT1 activation. Targeted delivery of TP via FN-binding CREKA-Lip enhances therapeutic efficacy while minimizing multi-organ toxicity.
Authors
- Liang Ma (ORCID: https://orcid.org/0000-0001-8327-7969)
- Ping Fu (ORCID: https://orcid.org/0000-0002-3061-5925)
- Rongshuang Huang
- Yanping Li (ORCID: https://orcid.org/0000-0003-1811-0083)
- Xinrui Li (ORCID: https://orcid.org/0000-0001-8466-1778)
- Fan Guo (ORCID: https://orcid.org/0000-0002-0165-073X)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-07-20
- DOI
- https://doi.org/10.12182/20250760503
- Citations
- 1
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.38