Integrative multi-omics and causal inference reveal periodontal ligament cell-macrophage crosstalk under orthodontic force
Orthodontic forces induce transcriptional reprogramming and proteomic remodeling in PDL cells, which drive CD40 signaling in monocytes through mechano-immunological coupling. These adaptations activate Cd40<sup>+</sup> macrophages, ultimately redefining orthodontic bone remodeling as a mechano-driven stromal-immune partnership essential for tooth movement.
Authors
- Jing Zhou (ORCID: https://orcid.org/0000-0002-0578-8074)
- Yang Jiang (ORCID: https://orcid.org/0000-0003-1100-9177)
- Yan Hong Huang (ORCID: https://orcid.org/0000-0001-5281-0783)
- Xiaobo Chen (ORCID: https://orcid.org/0000-0003-0283-0879)
- Yuming Bai (ORCID: https://orcid.org/0009-0005-0415-2882)
- Liping Huang (ORCID: https://orcid.org/0009-0006-3851-3604)
Institutions
- Xiamen University (CN)
- Xiamen Chang Gung Hospital (CN)
Publication Details
- Journal
- Progress in Orthodontics
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1186/s40510-025-00588-w
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59