Overexpression of Ku80 Protects Lens Epithelial Cells from Selenium-Induced Cataract Formation by Regulating the DNA Damage Response
Ku80 overexpression alleviates damage to LECs and postpones the development of selenium-induced cataracts by increasing CSB protein levels and controlling DNA repair processes. This research underscores the significant therapeutic potential of Ku80 in postponing cataract formation and may offer new avenues for gene therapy in the prevention and treatment of cataracts.
Authors
- Qianjie Yang (ORCID: https://orcid.org/0009-0004-0825-9719)
- Shanjun Wu (ORCID: https://orcid.org/0000-0002-9259-1965)
- Yun Wang (ORCID: https://orcid.org/0000-0003-3661-9959)
- Yiming Wang (ORCID: https://orcid.org/0000-0003-0513-9039)
- Kan Chen (ORCID: https://orcid.org/0000-0003-4429-9043)
- Pingping Chen (ORCID: https://orcid.org/0000-0002-2848-2465)
- Xiaotian Liu (ORCID: https://orcid.org/0000-0003-1331-9718)
- Yao Hongyan
- Jianshu Yuan
- Qinyi Gu
Institutions
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
Publication Details
- Journal
- Current Eye Research
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1080/02713683.2025.2575784
- Citations
- 1
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.81