The diet-derived gut microbial metabolite 3-phenylpropionic acid reverses insulin resistance and obesity-associated metabolic dysfunction
Our findings establish 3-phenylpropionic acid as a diet-derived, microbiota-dependent metabolite with insulin-sensitizing and anti-steatotic activities and provide a molecular basis for prebiotic interventions to improve host metabolic health.
Authors
- Beckey DeLucia (ORCID: https://orcid.org/0000-0001-5895-2408)
- Clifton G. Fulmer (ORCID: https://orcid.org/0000-0003-1453-9421)
- Jan Claesen (ORCID: https://orcid.org/0000-0002-0755-7974)
- Viharika Bobba (ORCID: https://orcid.org/0000-0003-3958-9388)
- Ina Nemet (ORCID: https://orcid.org/0000-0002-0657-7121)
- Lucas J. Osborn (ORCID: https://orcid.org/0000-0003-0077-9192)
- Rachel L. Markley (ORCID: https://orcid.org/0000-0003-2114-708X)
- Layan Hamidi Nia (ORCID: https://orcid.org/0000-0001-9566-5491)
- Sarah Preston (ORCID: https://orcid.org/0000-0002-4227-1664)
- Naseer Sangwan (ORCID: https://orcid.org/0000-0002-2407-769X)
- Sara Alqudah
- Tharika Thambidurai
Institutions
- Cleveland Clinic (US)
- Cleveland Clinic Lerner College of Medicine (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.molmet.2025.102272
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16