Seizure Frequency Trends Over Time in Treatment-Resistant Focal Epilepsy
Findings from the HEP2 study imply that FTRE improves over time, ASM additions had low probability of achieving seizure freedom but contributed to seizure reduction, and device-treated participants exhibited similar seizure trajectories to those without devices. Whether improvements reflected the natural history of FTRE or active management remains unclear, but our findings suggest cautious interpretation of open-label studies positing disease-modifying effects and further research into FTRE treatment response.
Authors
- Mikhail S. Gelfand (ORCID: https://orcid.org/0000-0003-4181-0846)
- Andrés M. Kanner (ORCID: https://orcid.org/0000-0003-2857-8034)
- Ojas Potnis (ORCID: https://orcid.org/0000-0003-1715-6063)
- Gregory D. Cascino (ORCID: https://orcid.org/0000-0002-5380-2977)
- Kimford J. Meador (ORCID: https://orcid.org/0000-0002-7471-882X)
- Brandy Fureman (ORCID: https://orcid.org/0000-0002-7862-4716)
- Kamil Detyniecki (ORCID: https://orcid.org/0000-0002-8334-1403)
- Gary Cutter (ORCID: https://orcid.org/0000-0002-8455-980X)
- Dennis Dlugos (ORCID: https://orcid.org/0000-0003-3088-7645)
- Hamada Hamid Altalib (ORCID: https://orcid.org/0000-0001-7154-1400)
- Manisha Holmes (ORCID: https://orcid.org/0000-0002-4262-0764)
- John Hixon
- Jacqueline A. French (ORCID: https://orcid.org/0000-0002-8756-6546)
- Caitlin L. Grzeskowiak (ORCID: https://orcid.org/0000-0003-1550-4466)
- Barry E. Gidal (ORCID: https://orcid.org/0000-0001-6681-7134)
- Paul Atkinson (ORCID: https://orcid.org/0000-0001-9900-4594)
- Heath Pardoe (ORCID: https://orcid.org/0000-0002-0123-2167)
- Ruben Kuzniecky (ORCID: https://orcid.org/0000-0002-3170-150X)
- Gabriel Biondo
- Rachel Sukonik
- Robert T. Wechsler
- Daniel H. Lowenstein (ORCID: https://orcid.org/0000-0002-5869-4020)
- Manu Hegde
- Bassel Abou-Khalil
- Chris Morrison
Institutions
- University of Notre Dame (US)
- Northwell Health (US)
- University of California, San Francisco (US)
- Epilepsy Foundation (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- NYU Langone Health (US)
- Investigators Research Group (United States) (US)
- Johns Hopkins Hospital (US)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1001/jamaneurol.2025.4085
- Citations
- 4
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.88