Effective treatment of pretibial myxoedema with tofacitinib: a case report and analysis of immunopathogenesis
Tofacitinib demonstrated rapid and durable efficacy in refractory PTM, likely by suppressing JAK-STAT-mediated fibroblast activation and pro-inflammatory cytokine release. This supports its role as a potential targeted oral therapy for PTM.
Authors
- Mingxia Zhao
- Xin Li (ORCID: https://orcid.org/0000-0002-7414-5734)
- Chenxi Zhao (ORCID: https://orcid.org/0000-0001-5666-4517)
Institutions
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Thyroid Research
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1186/s13044-025-00262-7
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00