A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer
Our work provides a novel mechanism by which c-MYC is activated in cancer cells by epigenetic silencing of its antisense RNA, which functions as a tumor suppressor.
Authors
- Gul Zaib (ORCID: https://orcid.org/0000-0003-3889-1665)
- Qi Xu (ORCID: https://orcid.org/0000-0003-2791-0429)
- Shihao Chen (ORCID: https://orcid.org/0000-0001-7646-8003)
- Xuming Hu (ORCID: https://orcid.org/0000-0002-6973-8252)
- Hengmi Cui (ORCID: https://orcid.org/0000-0001-5139-5370)
- Mingzhou Guo (ORCID: https://orcid.org/0000-0002-9445-9984)
- Chunfeng Dou
- Liping Wang (ORCID: https://orcid.org/0000-0002-6771-6498)
- Ye Wei (ORCID: https://orcid.org/0000-0003-1994-5664)
- Huixian Wu
- Meiying Zhang (ORCID: https://orcid.org/0009-0002-9104-7412)
- Wang Guo
- Xiaoyuan Wang (ORCID: https://orcid.org/0009-0009-2816-8933)
Institutions
- Jiangsu Second Normal University (CN)
- Chinese PLA General Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Ministry of Education (MV)
- Yangzhou University (CN)
- Epigenomics (Germany) (DE)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3389/fgene.2025.1552009
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Key Research and Development Program of China