Difference between estimated GFR based on cystatin C versus creatinine and incident dementia, cognitive functions and biological aging: A cohort study of the UK Biobank
A negative eGFR<sub>diff</sub> (eGFR<sub>cys</sub>-eGFR<sub>cr</sub> < -15 mL/min/1.73m<sup>2</sup>) was associated with a higher risk of dementia, poorer cognitive functions, and worse biological age acceleration. While those with a positive eGFR<sub>diff</sub> had a lower risk.
Authors
- Yiqun Li
- Yiming Jia (ORCID: https://orcid.org/0000-0002-3624-7879)
- Pinni Yang (ORCID: https://orcid.org/0000-0001-7327-3294)
- Mengyao Shi (ORCID: https://orcid.org/0000-0002-5883-0416)
- Lulu Sun
- Zhengbao Zhu (ORCID: https://orcid.org/0000-0002-4363-7357)
- Yonghong Zhang (ORCID: https://orcid.org/0000-0002-7740-9408)
- Ruirui Wang (ORCID: https://orcid.org/0000-0003-1445-2537)
- Wenyang Han
- Xiaowei Zheng (ORCID: https://orcid.org/0000-0002-0912-7062)
Institutions
- Jiangnan University (CN)
- Soochow University (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1016/j.exger.2025.112933
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00