Distinct genomic profile of pediatric lung carcinoma: High frequency of ALK fusions and TP53 mutations compared to adults

This study provides crucial insights into the genomic landscape across different types of pediatric lung cancer. We observed frequent presence of ALK fusions in pediatric LUAD + ASC, which are less common in adult LUAD. Other alterations in this subgroup showed resemblance with adult LUAD findings. In pediatric PMEC, we demonstrated the ubiquitous presence of MAML2 translocations. However, the conclusions of the study are limited due to the small sample size and potential artifacts from formalin-fixed paraffin-embedded samples. In summary, the results provide better understanding of the development of rare pediatric tumors and approaches for targeted therapies.

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Publication Details

Journal
Lung Cancer
Published
2025-10-20
DOI
https://doi.org/10.1016/j.lungcan.2025.108800
Citations
2
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
3.04
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article

Distinct genomic profile of pediatric lung carcinoma: High frequency of ALK fusions and TP53 mutations compared to adults

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2 citations
Lung Cancer
Lung Cancer Treatments and Mutations
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article

Distinct genomic profile of pediatric lung carcinoma: High frequency of ALK fusions and TP53 mutations compared to adults

Jakob Admard, Anton Karelin, Irina Bonzheim, Ines B. Brecht, Sorin Armeanu–Ebinger, Nicolas Waespe, Martin Reck, Andreas De Block, Christopher Schroeder, Alexandra Liebmann, Margo Hoover‐Regan, Ewa Bień, Małgorzata Krawczyk, Michaela Pogoda, Michael Abele, Ulrike Faust, Stephan Ossowski, Dominik T. Schneider
article en
2 citations

Abstract

This study provides crucial insights into the genomic landscape across different types of pediatric lung cancer. We observed frequent presence of ALK fusions in pediatric LUAD + ASC, which are less common in adult LUAD. Other alterations in this subgroup showed resemblance with adult LUAD findings. In pediatric PMEC, we demonstrated the ubiquitous presence of MAML2 translocations. However, the conclusions of the study are limited due to the small sample size and potential artifacts from formalin-fixed paraffin-embedded samples. In summary, the results provide better understanding of the development of rare pediatric tumors and approaches for targeted therapies.

Lung CancerVol. 209
University of Wisconsin–Madison (US), Universität Hamburg (DE), University Hospital of Bern (CH), University Medical Center Hamburg-Eppendorf (DE), University Children's Hospital Tübingen (DE), Klinikum Dortmund (DE), German Center for Lung Research (DE), Gdańsk Medical University (PL), University of Tübingen (DE)
Openalex Percentile: Top 8%
Lung Cancer Treatments and Mutations
3.04
DOIOpen Access PDFOpenAlex
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