Increased TGF-β/Activin-Smad2 signaling is associated with pancreatic β-cell dysfunction and glucose intolerance in gestational diabetes mellitus
Our data suggest that disruption of the pancreatic Smad2 pathway plays a critical role in the pathogenesis of GDM, contributing to abnormal glucose homeostasis and inadequate insulin secretion. Attenuation of this signaling pathway may represent a putative therapeutic target for GDM.
Authors
- Hilda Ferrero (ORCID: https://orcid.org/0000-0001-7960-7523)
- Paloma Alonso‐Magdalena (ORCID: https://orcid.org/0000-0003-1065-5388)
- Juan Martínez‐Pinna
- Sergi Soriano
- Iván Quesada
- Talía Boronat‐Belda (ORCID: https://orcid.org/0000-0002-6548-5251)
- Ãngel Nadal (ORCID: https://orcid.org/0000-0003-4178-2152)
- Elena Ribes-García
- Rubén Betoret-Gustems
- Daniel Martínez-Bañón
- Mónica Serrano-Selva
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Hospital Universitario del Vinalopó (ES)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1016/j.molmet.2025.102274
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00