Methionine ameliorates intestinal injury in senescence-accelerated mouse prone-8 mice by reducing sulfate-reducing bacteria and enhancing barrier function

A methionine-supplemented diet within the safe range significantly alleviates aging-induced intestinal barrier dysfunction by regulating the gut microbiota, inhibiting H₂S-producing bacteria, and restoring the host's intestinal sulfation capacity. A new microbiota- sulfation axis pathway was revealed, which promotes the metabolism of toxic sulfur substances related to the microbiota (such as H₂S, indoxyl sulfate, etc.), and methionine supplementation was proposed as a promising nutritional strategy to promote intestinal health and alleviate aging-related pathological changes.