Hsa-miR-181a-5p Enhances the Chemosensitivity of Breast Cancer Cells to Tamoxifen by Regulation of the OSBPL3/RAS Signaling Pathway
These results suggested that the upregulation of miR-181a-5p enhanced chemosensitivity to tamoxifen by negatively regulating OSBPL3 through the RAS signaling pathway in BC cells. Therefore, a treatment strategy based on the miR-181a-5p/OSBPL3 axis may represent a potential approach to overcoming tamoxifen resistance in BC.
Authors
- Xiaochun Fu (ORCID: https://orcid.org/0000-0001-6831-328X)
- Xiaojiao Qu
- Chenxi Li (ORCID: https://orcid.org/0009-0008-6029-7180)
- Xiujuan Li (ORCID: https://orcid.org/0000-0001-8203-8085)
- Sijia Cao (ORCID: https://orcid.org/0000-0002-4545-2997)
- Jianmin Lin
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
Publication Details
- Journal
- Cureus
- Published
- 2025-10-20
- DOI
- https://doi.org/10.7759/cureus.94996
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00