Dimethyl fumarate reprograms cervical cancer cells to enhance antitumor immunity by activating mtDNA-cGAS-STING pathway
This work elucidated that DMF reprograms CC cells to activate the mtDNA-cGAS-STING pathway, fostering a chemokine-rich microenvironment that recruits CD8<sup>+</sup> T cells. The synergistic effect of DMF and PD-1 blockade or TIL therapy underscores its potential as an immunostimulatory adjuvant. These findings suggest that DMF holds promise as a novel immunotherapeutic strategy for improving clinical outcomes in CC.
Authors
- Junyan Han (ORCID: https://orcid.org/0000-0002-5266-033X)
- Yafei Huang (ORCID: https://orcid.org/0000-0002-1711-2354)
- Shen Qu (ORCID: https://orcid.org/0000-0003-0811-7070)
- Yifan Yang (ORCID: https://orcid.org/0000-0001-9127-168X)
- Min‐Hsien Wu (ORCID: https://orcid.org/0000-0002-3507-3512)
- Ying Chen (ORCID: https://orcid.org/0000-0001-5833-2380)
- Guijie Kang
- Liming Wang (ORCID: https://orcid.org/0000-0003-3354-2079)
- Zixuan Wang (ORCID: https://orcid.org/0009-0009-1157-3027)
- Hui Wang (ORCID: https://orcid.org/0000-0003-4112-5494)
- Qiangqiang Wang (ORCID: https://orcid.org/0000-0002-5506-6539)
- Shan He (ORCID: https://orcid.org/0000-0002-8558-7490)
- Ting Ye (ORCID: https://orcid.org/0000-0002-5704-400X)
- Wenjing Tian (ORCID: https://orcid.org/0000-0002-0449-6643)
- Han Jiang (ORCID: https://orcid.org/0009-0009-6200-2742)
- Li‐Ting Liu (ORCID: https://orcid.org/0000-0002-7641-4774)
- Hangyu Liu
- Yuwei Zhang (ORCID: https://orcid.org/0009-0008-1016-7361)
Institutions
- Union Hospital (HK)
- Ministry of Education of the People's Republic of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Saudi Center for Organ Transplantation (SA)
- Wuhan Union Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Hangzhou Medical College (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1186/s12929-025-01187-x
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59