Relationship between Ventilation/Perfusion Ratio Mismatch and Capnogram Phase III Slope in Acute Bronchoconstriction and Its Modulation by Salbutamol Assessed by Synchrotron Imaging in Rabbit Lung
SIII is determined not only by heterogeneity but also by and its heterogeneity. The lack of improvement or paradoxical worsening in gas exchange despite mechanical improvement after salbutamol in acute bronchoconstriction is due to increased perfusion of low regions and shunt fraction. These findings provide new insight into monitoring mechanical ventilation and acute bronchoconstriction with capnography.
Authors
- Liisa Porra (ORCID: https://orcid.org/0000-0003-3639-944X)
- Gergely H. Fodor (ORCID: https://orcid.org/0000-0002-4736-4966)
- Gergely Albu (ORCID: https://orcid.org/0000-0002-7508-8567)
- Sam Bayat (ORCID: https://orcid.org/0000-0002-8565-0293)
- Ferenc Peták (ORCID: https://orcid.org/0000-0001-6249-9327)
- Barna Babik (ORCID: https://orcid.org/0000-0003-3739-8879)
- Mathieu Guilbart (ORCID: https://orcid.org/0000-0001-9942-1953)
Institutions
- University of Geneva (CH)
- Inserm (FR)
- University of Szeged (HU)
- Helsinki University Hospital (FI)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- University Hospital of Geneva (CH)
- Grenoble Institute of Neurosciences (FR)
- Geneva College (US)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1097/aln.0000000000005807
- Citations
- 1
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.52