Palladium-Catalyzed Hiyama Cross-Coupling of Arylsulfonium Salts via C–S Bond Cleavage
We report a palladium-catalyzed Hiyama-type coupling of arylsulfonium salts with structurally diverse arylsilanes via C(sp<sup>2</sup>)-S bond cleavage. This desulfitative transformation accommodates a broad substrate scope with remarkable functional group compatibility, which could also be conducted in a one-pot, telescoped procedure from aryl thioether without isolation. The utility of this methodology has been underscored by the gram-scale synthesis, formal C(sp<sup>2</sup>)-H Hiyama-type coupling, and concise late-stage modification of pharmaceutically relevant molecules.
Authors
- Teck‐Peng Loh (ORCID: https://orcid.org/0000-0002-2936-337X)
- Xing Zhou (ORCID: https://orcid.org/0000-0002-4674-3585)
- Mingzhu Lu (ORCID: https://orcid.org/0000-0002-6333-0803)
- Meng Li (ORCID: https://orcid.org/0000-0003-3540-7604)
- Min‐Zhi Deng (ORCID: https://orcid.org/0009-0000-1960-5294)
- Rui Yang (ORCID: https://orcid.org/0009-0007-3053-7078)
Institutions
- Nanyang Technological University (SG)
- Henan University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c03847
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00