p53 Drives Lung Cancer Regression through a TSC2/TFEB-dependent Senescence Program
Cancer therapies based on targeting the p53 pathway remain elusive. To address this gap, we unravel the detailed sequence of events governing p53-induced tumor regression in lung adenocarcinoma. These analyses reveal a TSC2-mTORC1-TFEB axis underlying p53-driven senescence and tumor regression, which suggests new strategies to perfect p53-based combination therapies for lung adenocarcinoma.
Authors
- Nam Q. Bui (ORCID: https://orcid.org/0000-0001-6896-4349)
- Tianyu Zhao (ORCID: https://orcid.org/0000-0002-1120-7272)
- Christopher T. Chen (ORCID: https://orcid.org/0000-0001-8962-3527)
- Elsa R. Flores (ORCID: https://orcid.org/0000-0002-6173-2403)
- John H. Lockhart (ORCID: https://orcid.org/0000-0002-2727-6969)
- Laura D. Attardi (ORCID: https://orcid.org/0000-0003-1782-9045)
- Nitin Raj (ORCID: https://orcid.org/0000-0001-7678-3855)
- Alyssa M. Kaiser
- Kathryn Bieging-Rolett
- Arielle Elkrief (ORCID: https://orcid.org/0000-0003-1981-1535)
- Marc Ladanyi (ORCID: https://orcid.org/0000-0001-9055-7213)
- Mengxiong Wang (ORCID: https://orcid.org/0000-0002-8290-151X)
- Kha The Nguyen (ORCID: https://orcid.org/0000-0001-9191-8754)
- Simone A. Evans
- Sam E. Tischfield
- Sofia Ferreira (ORCID: https://orcid.org/0000-0001-9535-2161)
- Arati Rajeevan (ORCID: https://orcid.org/0000-0002-8699-5816)
- Michael G. Ozawa
- Colleen A. Brady
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Palo Alto University (US)
- Moffitt Cancer Center (US)
- FuelCell Energy (United States) (US)
- Stanford Medicine (US)
- Centre Hospitalier de l’Université de Montréal (CA)
- Stanford University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0525
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Tobacco-Related Disease Research Program
- Gilead Sciences
- National Cancer Institute