Cytokine and Chemokine Profiles in Anti-LGI1 Encephalitis
In this study, we show that the acute-phase IL-6 CSF/serum ratio and serum IL-35 levels in immunotherapy-naive patients with anti-LGI1 encephalitis are associated with disease severity and poor outcomes, respectively, highlighting their potential as biomarkers for risk stratification and therapeutic targeting.
Authors
- Eugenia Martínez‐Hernández (ORCID: https://orcid.org/0000-0002-8317-7068)
- Jordi Estela-Herrero
- Mario Riverol (ORCID: https://orcid.org/0000-0002-4383-9127)
- Amaia Muñoz‐Lopetegi (ORCID: https://orcid.org/0000-0002-8852-0187)
- Francesc Graus (ORCID: https://orcid.org/0000-0002-8924-8322)
- Nicolau Guanyabens (ORCID: https://orcid.org/0000-0002-2074-2744)
- Lídia Sabater (ORCID: https://orcid.org/0000-0001-8556-6166)
- María Elena Erro (ORCID: https://orcid.org/0000-0002-9707-4190)
- Manuel Palacı́n (ORCID: https://orcid.org/0000-0002-8670-293X)
- Alba Chavarría‐Miranda (ORCID: https://orcid.org/0000-0002-7368-4939)
- Raquel Ruiz‐García (ORCID: https://orcid.org/0000-0002-8403-3613)
- Guillermo Muñoz‐Sánchez (ORCID: https://orcid.org/0000-0002-0308-6255)
- L. Aguilar (ORCID: https://orcid.org/0000-0002-1553-2224)
- Gary Álvarez Bravo (ORCID: https://orcid.org/0000-0003-0342-0177)
- M. Alba Mañé-Martínez (ORCID: https://orcid.org/0000-0002-8901-4534)
- Elvira Munteis
- María J. Sedano Tous
- Takahiro Iizuka (ORCID: https://orcid.org/0000-0002-7234-0720)
- Mar Guasp (ORCID: https://orcid.org/0000-0002-0110-5213)
- Josep Dalmau (ORCID: https://orcid.org/0000-0001-5856-2813)
- Imma Pericot Nierga (ORCID: https://orcid.org/0000-0003-0621-4264)
- Albert Saiz (ORCID: https://orcid.org/0000-0002-5793-8791)
- María José García Gomara
- Rocío Soledad Couso
- José Barberá
- Mateus Mistieri Simabukuro (ORCID: https://orcid.org/0000-0001-9243-3337)
- Ana L. Pelayo‐Negro
- Laura Naranjo (ORCID: https://orcid.org/0000-0001-9295-1468)
- María Angustias Romera
- Manuel González Barón
- A. Giménez-Muñoz
- Juan Francisco Luchoro
- Albertí Gonzalez Olalla
- F. Ortega-Valin
- I. González-Aramburu
- C.J. de Miguel-Sanchez
- J.P. Fernandez-Cubillos
Institutions
- Universidade de São Paulo (BR)
- Hospital de Sant Pau (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Navarrabiomed (ES)
- Institut Infància (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Kitasato University (JP)
- Universitat de Barcelona (ES)
- University of Pennsylvania (US)
- Philadelphia University (US)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1212/nxi.0000000000200492
- Citations
- 1
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39