Disrupting Paraspeckle Stability by Targeting WTX–NONO Phase Separation Enhances Chemotherapy Efficacy in Gastric Cancer
WTX binding to NONO regulates the balance of biomolecular condensates, providing an axis that can be harnessed to perturb paraspeckles and improve chemotherapy sensitivity in gastric cancer.
Authors
- Yangwei Xu (ORCID: https://orcid.org/0000-0003-4534-2031)
- Jun-Ping Bai
- Yi‐Chuan Li (ORCID: https://orcid.org/0000-0002-1795-1051)
- H. Zhang
- Zhangting Zhao (ORCID: https://orcid.org/0000-0002-4481-946X)
- Zaisheng Ye (ORCID: https://orcid.org/0000-0001-9881-6400)
- Zhihao Lin (ORCID: https://orcid.org/0009-0003-7158-4787)
- Mien‐Chie Hung (ORCID: https://orcid.org/0000-0003-4317-4740)
- Xuanqi Li (ORCID: https://orcid.org/0000-0002-7511-8789)
- Liwei An (ORCID: https://orcid.org/0000-0003-4514-5476)
- Qingling Zhang (ORCID: https://orcid.org/0000-0002-5287-264X)
- Zetao Chen (ORCID: https://orcid.org/0000-0002-9802-8065)
- Li-Jun Han
- Fei Sun
- Meng Du
- YanYan Li (ORCID: https://orcid.org/0000-0002-9354-647X)
- Xuexia Qian
Institutions
- Tongji University (CN)
- Fujian Medical University (CN)
- Shanxi Medical University (CN)
- China Medical University (TW)
- Key Laboratory of Guangdong Province (CN)
- Shanxi Provincial Cancer Hospital (CN)
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Second Hospital of Shanxi Medical University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Fujian Provincial Cancer Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- State Key Laboratory of Bioreactor Engineering
- Southern Medical University (CN)
- Texas A&M University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1747
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.81