Oxidative stress-regulatory role of miR-10b-5p in the diabetic human cornea revealed through integrated multi-omics analysis
Our findings suggest that diabetes-overexpressed miR-10b disrupts redox balance by targeting GCLM and LANCL1, which potentially leads to increased oxidative stress and cellular vulnerability in diabetic corneas. Inhibiting miR-10b-5p restored antioxidant defences, suggesting a potential therapeutic strategy to mitigate oxidative stress and normalise corneal health in individuals with diabetes and preserve vision.
Authors
- Jennifer E. Van Eyk (ORCID: https://orcid.org/0000-0001-9050-148X)
- Ruchi Shah (ORCID: https://orcid.org/0000-0002-9533-1747)
- Mehrnoosh Saghizadeh
- Andrei A. Kramerov
- Aleksandr Stotland (ORCID: https://orcid.org/0000-0003-4794-1097)
- Alexander V. Ljubimov (ORCID: https://orcid.org/0000-0003-2398-5319)
- Adam J. Poe
- Zhiping Paul Wang
- Nagendra Verma (ORCID: https://orcid.org/0000-0002-3149-7764)
- Chintda Santiskulvong
- Yizhou Wang (ORCID: https://orcid.org/0000-0002-9378-745X)
- S.W. White (ORCID: https://orcid.org/0000-0002-9209-6120)
- Onkar B. Sawant
- Shaghaiegh M. Ebrahimi
- Joshua Gamez
- Daxian Zha
Institutions
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- Cedars-Sinai Smidt Heart Institute (US)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1007/s00125-025-06558-5
- Citations
- 1
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Cedars-Sinai Medical Center