Activation of Sirtuin3 by 6,4′-Dihydroxy-7-methoxyflavanone Against Myoblasts Senescence by Attenuating D-Galactose-Induced Oxidative Stress and Inflammation
Our findings demonstrate that DMF alleviates myoblasts senescence and promotes myogenic differentiation by activating the SIRT3-SOD2 pathway, thereby reducing oxidative stress and NF-κB-driven inflammation responses. DMF emerges as a promising therapeutic candidate for sarcopenia.
Authors
- Zongren Wan
- Zhian Liu (ORCID: https://orcid.org/0000-0002-7200-2764)
- Yuxin Gu
- Libing Zhou (ORCID: https://orcid.org/0000-0002-8975-5228)
- Renlei Ji (ORCID: https://orcid.org/0000-0001-6258-1777)
- Yiwei Liu (ORCID: https://orcid.org/0009-0004-4657-7793)
- Bingsi Li (ORCID: https://orcid.org/0000-0002-2114-3647)
- Rui Chen (ORCID: https://orcid.org/0000-0002-7840-2785)
- Yukang Wang (ORCID: https://orcid.org/0000-0003-0788-7364)
- Ziyi Liang (ORCID: https://orcid.org/0000-0002-0354-3524)
Institutions
- Harvard University (US)
- Xuzhou Medical College (CN)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Nutrients
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3390/nu17203298
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Xuzhou Medical University