Visceral Pleural Invasion as a Determinant of Surgical Strategy in Non–Small Cell Lung Cancer: A Multicenter Study
Our findings suggest that VPI is not merely a histopathological descriptor but also acts as a clinically significant indicator of aggressive metastatic behavior, potentially enhancing surgical and staging approaches beyond just considering tumor size. With the increasing adoption of sublobar resection for small-sized NSCLC, recognizing that VPI appears to be associated with predominant hilar involvement and an elevated risk of skip N2 metastasis may help refine decisions on the extent of lung and lymph node resection.
Authors
- Norihiko Ikeda
- Masatoshi Kakihana (ORCID: https://orcid.org/0000-0003-1737-6883)
- Takahiro Mimae (ORCID: https://orcid.org/0000-0001-9993-8928)
- Yujin Kudo (ORCID: https://orcid.org/0000-0003-3187-9970)
- Takuya Nagashima (ORCID: https://orcid.org/0000-0002-1563-6867)
- Yoshihiro Miyata (ORCID: https://orcid.org/0000-0002-4598-1231)
- Hiroyuki Ito (ORCID: https://orcid.org/0000-0002-9450-0027)
- Yoshihisa Shimada (ORCID: https://orcid.org/0000-0003-3811-6159)
- Tatsuo Ohira (ORCID: https://orcid.org/0000-0002-7927-6987)
- Morihito Okada (ORCID: https://orcid.org/0000-0002-0601-3828)
- Masaru Hagiwara
- Wakako Nagase
Institutions
- Hiroshima University (JP)
- Tokyo Medical University (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- Kanagawa Cancer Center
Publication Details
- Journal
- Cancers
- Published
- 2025-10-20
- DOI
- https://doi.org/10.3390/cancers17203382
- Citations
- 1
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52