Self-Sufficient Aflatoxin Decontamination System: MOF-Based Composite Membrane with Peroxidase-Mimic and Controlled H2O2 Generation

Aflatoxin B1 (AFB1) and its metabolite aflatoxin M1 (AFM1) are stable and carcinogenic mycotoxins that are commonly found in dairy products, posing serious food safety concerns. However, conventional degradation methods face limited degradation efficiency and high energy demand. Here, we develop an innovative polyvinylidene fluoride (PVDF) composite membrane incorporating Fe/Co-based metal-organic frameworks (MOF) (Named Fe/Co-MIL-88B(NH₂)) and CaO₂ for targeted aflatoxin removal from milk. This system integrates two synergistic mechanisms: (1) hierarchical porous MOF structures enabling superior aflatoxin adsorption capacity and peroxidase-like catalytic activity, and (2) CaO₂ acts as a controllable-release H₂O₂ donor, supplying a steady flux of reactive oxygen species without the addition of exogenous H₂O₂. Moreover, the PVDF membrane with mechanical stability offers uniform immobilization of active components, which prevents the aggregation of nanozymes. As a result, the integrated membrane achieves high degradation efficiency for AFB1 and AFM1, exceeding 95% within 60 min. By eliminating external oxidant addition and minimizing collateral nutrient damage, the technology demonstrates remarkable operational stability (>10 cycles) and milk quality preservation capability. This breakthrough establishes an efficient and reusable detoxification method, providing new opportunities for mycotoxin mitigation in dairy products through spatiotemporal control of reactive oxygen species.