Metamizole-Induced Agranulocytosis: A Case Report

Metamizole, a widely used analgesic and antipyretic, has been associated with rare but potentially life-threatening hematological adverse reactions, such as agranulocytosis. This case report highlights the diagnostic complexity and clinical management of a patient who presented with neutropenic fever and concurrent multidrug-resistant infections, ultimately found to be related to metamizole-induced agranulocytosis. It underlines the importance of considering drug-induced causes in the differential diagnosis of agranulocytosis and stresses the relevance of early identification and prompt discontinuation of the causative agent.

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Publication Details

Journal
Cureus
Published
2025-10-20
DOI
https://doi.org/10.7759/cureus.94983
Citations
1
Primary Topic
Blood disorders and treatments
Type
article
Field-Weighted Citation Impact
1.82
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article

Metamizole-Induced Agranulocytosis: A Case Report

Maria do Rosário Ginga, Carla Fernandes, Joana Cartucho, Ana Ruivo et al.
1 citations
Cureus
Blood disorders and treatments
1.82
article

Metamizole-Induced Agranulocytosis: A Case Report

Maria do Rosário Ginga, Carla Fernandes, Joana Cartucho, Ana Ruivo, Ines Bonito
article en
1 citations

Abstract

Metamizole, a widely used analgesic and antipyretic, has been associated with rare but potentially life-threatening hematological adverse reactions, such as agranulocytosis. This case report highlights the diagnostic complexity and clinical management of a patient who presented with neutropenic fever and concurrent multidrug-resistant infections, ultimately found to be related to metamizole-induced agranulocytosis. It underlines the importance of considering drug-induced causes in the differential diagnosis of agranulocytosis and stresses the relevance of early identification and prompt discontinuation of the causative agent.

CureusVol. 17(10)
Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
Openalex Percentile: Top 12%
Blood disorders and treatments
1.82
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