HLA-DRB1*15:01 is associated with a reduced likelihood of longevity in northern European men
The novel male-specific association between HLA-DRB1*15:01 and longevity has been observed in three independent cohorts. The anti-longevity effect of this association is perhaps a consequence of an increase in Alzheimer's disease (AD)-related mortality in men carrying this allele. This hypothesis is based on prior research that has identified a male-specific association between HLA-DRB1*15:01:01 and AD. Additionally, it is likely that this link is mediated by increased immune reactivity against APOB-100, which is promoted by HLA-DRB1*15:01:01.
Authors
- Guillermo G. Torres (ORCID: https://orcid.org/0000-0002-4548-7815)
- Janina Dose (ORCID: https://orcid.org/0000-0002-1145-509X)
- Nicolás Mendoza-Mejía
- Marianne Nygaard (ORCID: https://orcid.org/0000-0003-0703-2665)
- Onur Özer (ORCID: https://orcid.org/0000-0003-2284-6181)
- Almut Nebel
- André Franke (ORCID: https://orcid.org/0000-0003-1530-5811)
- Daniel Kolbe (ORCID: https://orcid.org/0000-0002-6607-7591)
Institutions
- University of Southern Denmark (DK)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Hospital Schleswig-Holstein (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1186/s13073-025-01554-1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft