Primary Versus Secondary Non-Urothelial Tumors Involving the Bladder: A 10-Year Analysis of Clinicopathologic Profiles and Adverse Feature Burden

Secondary bladder involvement carries substantially higher adverse-pathology rates than primary non-urothelial tumors, with origin-specific risk gradients (prostate > colorectal ≳ cervix). Rigorous origin adjudication and a margin-focused, anatomy-adapted surgical strategy may improve outcomes; prospective outcome-linked validation is warranted.

Authors

Sorin Dema (ORCID: https://orcid.org/0000-0002-6877-3718)
Răzvan Bardan (ORCID: https://orcid.org/0000-0002-8288-5468)
Alexei Croitor
Diana Herman
Alin Adrian Cumpănaş (ORCID: https://orcid.org/0000-0002-4071-9824)
Vlad Dema
Mihail Nanu

Institutions

Clinical Emergency Hospital Bucharest (RO)
Spitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara (RO)
Victor Babeș University of Medicine and Pharmacy Timișoara (RO)

Publication Details

Journal: Cancers
Published: 2025-10-18
DOI: https://doi.org/10.3390/cancers17203369
Primary Topic: Urinary and Genital Oncology Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Primary Versus Secondary Non-Urothelial Tumors Involving the Bladder: A 10-Year Analysis of Clinicopathologic Profiles and Adverse Feature Burden

Sorin Dema, Răzvan Bardan, Alexei Croitor, Diana Herman et al.

Oct 18, 2025

Cancers

Urinary and Genital Oncology Studies

article

Primary Versus Secondary Non-Urothelial Tumors Involving the Bladder: A 10-Year Analysis of Clinicopathologic Profiles and Adverse Feature Burden

Sorin Dema, Răzvan Bardan, Alexei Croitor, Diana Herman, Alin Adrian Cumpănaş, Vlad Dema, Mihail Nanu

October 18, 2025article en

Abstract

Secondary bladder involvement carries substantially higher adverse-pathology rates than primary non-urothelial tumors, with origin-specific risk gradients (prostate > colorectal ≳ cervix). Rigorous origin adjudication and a margin-focused, anatomy-adapted surgical strategy may improve outcomes; prospective outcome-linked validation is warranted.

CancersVol. 17(20)

Clinical Emergency Hospital Bucharest (RO), Spitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara (RO), Victor Babeș University of Medicine and Pharmacy Timișoara (RO)

Openalex Percentile: Top 53%

Urinary and Genital Oncology Studies

DOI Open Access PDF OpenAlex

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Primary Versus Secondary Non-Urothelial Tumors Involving the Bladder: A 10-Year Analysis of Clinicopathologic Profiles and Adverse Feature Burden — Sorin Dema, Răzvan Bardan, et al. · Cancers (2025) | TGRS Research Map | TGRS