ALDH2/eIF3E Interaction Modulates Protein Translation Critical for Cardiomyocyte Ferroptosis in Acute Myocardial Ischemia Injury
ALDH2*2 aggravates acute heart failure after MI by promoting the selective translation of mRNAs containing the GAGGACR motif, thereby driving cardiomyocyte ferroptosis. Targeting ferroptosis represents a potential therapeutic option for mitigating MI injury, especially for ALDH2*2 carriers.
Authors
- Aijun Sun (ORCID: https://orcid.org/0000-0003-1488-0937)
- Ping Sha
- Dewen Yan (ORCID: https://orcid.org/0000-0003-4998-2853)
- Haoran Ma (ORCID: https://orcid.org/0000-0001-7993-3687)
- Weiyuan Wang (ORCID: https://orcid.org/0000-0003-0009-0467)
- Luxiao Li
- Xiaodong Xu (ORCID: https://orcid.org/0000-0002-5290-9705)
- Ningning Liang (ORCID: https://orcid.org/0000-0003-1439-7929)
- Yanwen Ye
- Hui Huang (ORCID: https://orcid.org/0000-0001-5716-4012)
- Huang‐Tian Yang (ORCID: https://orcid.org/0000-0002-6297-9037)
- Xiujian Yu
- Xin Chen (ORCID: https://orcid.org/0000-0003-3668-4830)
- Rui Li (ORCID: https://orcid.org/0000-0002-3199-287X)
- Lili Zhang (ORCID: https://orcid.org/0000-0002-4321-0521)
- Jinwei Tian (ORCID: https://orcid.org/0000-0002-2730-0033)
- Shiting Chen (ORCID: https://orcid.org/0000-0003-1741-9222)
- Chunzhao Yin
- Yongqiang Wang (ORCID: https://orcid.org/0000-0002-7276-4275)
- Pan Li (ORCID: https://orcid.org/0009-0002-0724-924X)
- Huiyong Yin (ORCID: https://orcid.org/0000-0001-7049-1560)
- Tongwei Lv
- Songfa Zhong
- Mingyao Zhou (ORCID: https://orcid.org/0000-0003-4804-8057)
- Jingyu Zhang (ORCID: https://orcid.org/0009-0003-9810-0455)
Institutions
- Harbin Medical University (CN)
- Sun Yat-sen University (CN)
- City University of Hong Kong (HK)
- Second Military Medical University (CN)
- Chengdu Medical College (CN)
- Fudan University (CN)
- ShanghaiTech University (CN)
- Shanghai Institute of Nutrition and Health (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Center for Excellence in Molecular Cell Science (CN)
- Zhongshan Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Second People's Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Circulation
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1161/circulationaha.125.075220
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07