Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway
The variation in heart rate in phase with breathing is called respiratory heart rate variability (RespHRV). Relaxation and positive socio-emotional states can amplify RespHRV, yet the underlying mechanism remains largely unknown. Here we identify a hypothalamus-brainstem neuronal pathway in rodents through which oxytocin (OT) amplifies RespHRV during calming behavior. OT neurons from the caudal paraventricular nucleus in the hypothalamus regulate the activity of a subgroup of inhibitory neurons in the pre-Bötzinger complex, the brainstem nucleus that generates the inspiratory rhythm. Specifically, OT enhances the glycinergic input from OT-receptor-expressing neurons in the pre-Bötzinger complex to cardiac-innervating parasympathetic neurons in the nucleus ambiguus during inspiration. This leads to amplified respiratory modulation of parasympathetic activity to the heart, thereby enhancing RespHRV. We show that OT neurons participate in the restoration of RespHRV amplitude during recovery from stress in mice, indicating that OT acts centrally to regulate cardiac activity during a calming behavior.
Authors
- Julie Buron (ORCID: https://orcid.org/0000-0002-1111-9416)
- Muriel Thoby‐Brisson (ORCID: https://orcid.org/0000-0003-3214-1724)
- Fabienne Schaller (ORCID: https://orcid.org/0000-0002-6977-0463)
- Valéry Matarazzo (ORCID: https://orcid.org/0000-0002-0833-203X)
- Christian Gestreau (ORCID: https://orcid.org/0000-0001-5069-482X)
- Marie‐Solenne Félix (ORCID: https://orcid.org/0000-0003-3271-3964)
- Roman Tyzio (ORCID: https://orcid.org/0000-0003-4419-9763)
- Françoise Muscatelli (ORCID: https://orcid.org/0000-0003-4001-6528)
- Ambre Linossier (ORCID: https://orcid.org/0009-0008-9641-3163)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Johns Hopkins University (US)
- Université de Bordeaux (FR)
- Inserm (FR)
- Aix-Marseille Université (FR)
- Johns Hopkins Medicine (US)
- Institut de Neurosciences Cognitives et Intégratives d’Aquitaine (FR)
- Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille (FR)
- Institut de Neurobiologie de la Méditerranée (FR)
- Génétique Médicale & Génomique Fonctionelle (FR)
- Centre de Génétique Médicale de Marseille (FR)
- University of Lausanne (CH)
Publication Details
- Journal
- Nature Neuroscience
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1038/s41593-025-02074-2
- Citations
- 4
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 9.75