Hypercontractility and Oxidative Stress Drive Creatine Kinase Dysfunction in Hypertrophic Cardiomyopathy
This study reveals a mechanistic link between hypercontractility, mitochondrial reactive oxygen species, and CK dysfunction in HCM, perpetuating a cycle of energetic dysfunction. Targeting hypercontractility and oxidative stress through myosin inhibition offers a strategy to restore energy balance and reduce arrhythmic risk in HCM.
Authors
- Nazha Hamdani (ORCID: https://orcid.org/0000-0002-3053-0008)
- Jan M. Federspiel (ORCID: https://orcid.org/0000-0002-9325-2658)
- Cristobal G. dos Remedios (ORCID: https://orcid.org/0000-0003-1052-7490)
- Craig A. Lygate (ORCID: https://orcid.org/0000-0001-6079-0284)
- Jolanda van der Velden (ORCID: https://orcid.org/0000-0001-5224-5788)
- Felix Stadler
- Anton Xu
- Thomas Eschenhagen (ORCID: https://orcid.org/0000-0003-1750-1170)
- Michelle Michels (ORCID: https://orcid.org/0000-0001-6432-0431)
- Letícia Prates Roma (ORCID: https://orcid.org/0000-0001-9527-0529)
- David Weissman (ORCID: https://orcid.org/0000-0002-4579-0777)
- Sevasti Zervou (ORCID: https://orcid.org/0000-0002-4665-2747)
- Edoardo Bertero (ORCID: https://orcid.org/0000-0002-3175-8151)
- Smita Scholtz (ORCID: https://orcid.org/0000-0002-7445-5986)
- Melina Tangos
- Vasco Sequeira (ORCID: https://orcid.org/0000-0002-9192-7674)
- Lucie Carrier (ORCID: https://orcid.org/0000-0001-8776-5820)
- Jan Dudek (ORCID: https://orcid.org/0000-0002-5672-7458)
- Sean Lal (ORCID: https://orcid.org/0000-0002-5841-560X)
- Michael Kohlhaas (ORCID: https://orcid.org/0000-0001-6132-6037)
- Christoph Maack (ORCID: https://orcid.org/0000-0003-3694-4559)
- Diederik W.D. Kuster (ORCID: https://orcid.org/0000-0003-1498-6862)
- Inês Falcão‐Pires (ORCID: https://orcid.org/0000-0003-1937-3782)
- Mark T. Waddingham (ORCID: https://orcid.org/0000-0002-0058-9455)
- Jan‐Christian Reil (ORCID: https://orcid.org/0000-0003-1053-5175)
- James T. Pearson (ORCID: https://orcid.org/0000-0002-3318-5406)
- Katharina J. Ermer
- Christopher N. Johnson (ORCID: https://orcid.org/0000-0002-5307-798X)
- Alexander Nickel (ORCID: https://orcid.org/0000-0002-7761-0769)
- Elisa Grünler
Institutions
- The University of Sydney (AU)
- Charles Sturt University (AU)
- Universität Hamburg (DE)
- Universidade do Porto (PT)
- Victor Chang Cardiac Research Institute (AU)
- University of Würzburg (DE)
- University Hospitals of the Ruhr-University of Bochum (DE)
- Heart and Diabetes Center North Rhine-Westphalia (DE)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Amsterdam Neuroscience (NL)
- University Medical Center Hamburg-Eppendorf (DE)
- National Cerebral and Cardiovascular Center (JP)
- Universitätsklinikum Würzburg (DE)
- German Centre for Cardiovascular Research (DE)
- Monash University (AU)
- University of Glasgow (GB)
- University of Genoa (IT)
- Ruhr University Bochum (DE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Erasmus University Rotterdam (NL)
- Saarland University (DE)
- Mississippi State University (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1161/circulationaha.125.074120
- Citations
- 3
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.16