Plasma Metabolomic and Proteomic Signatures of Blood Pressure Management After Bariatric Surgery Among Adolescents
This is the first study identifying potential preoperative biomarkers for EBP reductions in adolescents following bariatric surgery. Integrating metabolomics and proteomics with known risk factors substantially improved predictive models compared with known-risk-factors-only models. Larger and more diverse cohorts are needed to confirm these findings and whether identified features are associated with other blood pressure treatments.
Authors
- Tanya L. Alderete (ORCID: https://orcid.org/0000-0002-7751-9543)
- David V. Conti (ORCID: https://orcid.org/0000-0002-2941-7833)
- Justin R. Ryder (ORCID: https://orcid.org/0000-0002-7506-9497)
- Sandrah Proctor Eckel (ORCID: https://orcid.org/0000-0001-6050-7880)
- Lida Chatzi (ORCID: https://orcid.org/0000-0002-3319-2438)
- Sarah Rock (ORCID: https://orcid.org/0000-0002-9851-2594)
- Thomas H. Inge (ORCID: https://orcid.org/0000-0001-7782-1112)
- Max T. Aung (ORCID: https://orcid.org/0000-0001-5541-5447)
- Juan Pablo Lewinger (ORCID: https://orcid.org/0000-0002-0692-2570)
- Erika Garcia (ORCID: https://orcid.org/0000-0003-1540-9805)
- H. Wang
- Shudi Pan (ORCID: https://orcid.org/0000-0003-2583-2607)
- Jesse A. Goodrich (ORCID: https://orcid.org/0000-0001-6615-0472)
- Stephen R. Daniels (ORCID: https://orcid.org/0000-0001-5520-6952)
- Douglas I. Walker (ORCID: https://orcid.org/0000-0003-2912-398X)
- Todd Jenkins (ORCID: https://orcid.org/0000-0003-2669-3813)
- Michele A. La Merrill (ORCID: https://orcid.org/0000-0002-5720-5862)
- Frank D. Gilliland (ORCID: https://orcid.org/0000-0002-9033-7269)
- Jiawen Chen (ORCID: https://orcid.org/0000-0002-6022-9646)
- Zhenjiang Li (ORCID: https://orcid.org/0000-0002-4806-6231)
- Zhanghua Chen (ORCID: https://orcid.org/0000-0002-6424-6697)
- Stephanie Sisley
- Rob McConnell
Institutions
- University of Southern California (US)
- Cincinnati Children's Hospital Medical Center (US)
- Johns Hopkins University (US)
- Emory University (US)
- Lurie Children's Hospital (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- University of Colorado Anschutz Medical Campus (US)
- University of California, Davis (US)
- University of Cincinnati Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Hypertension
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25261
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16