Claudin proteins and hemorrhage severity in aneurysmal subarachnoid hemorrhage: Correlation with modified Fisher score but not functional outcome
Elevated serum CLDN3 and especially CLDN5 levels reflect hemorrhage extent and potential BBB disruption in aSAH. Their strong correlation with mFS suggests utility in grading imageological hemorrhagic severity, though not in predicting long-term functional outcomes. CLDN5 emerges as a promising biomarker for early assessment of BBB integrity in neurovascular injury.
Authors
- Gábor J. Szebeni (ORCID: https://orcid.org/0000-0002-6998-5632)
- Nikolett Gémes (ORCID: https://orcid.org/0000-0003-2028-1666)
- Péter Csécsei (ORCID: https://orcid.org/0000-0002-4982-2481)
- Fanni Balogh
- Gábor Lenzsér
- Attila Schwarcz
Institutions
- University of Szeged (HU)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
- University of Pecs (HU)
Publication Details
- Journal
- Neurosurgical Review
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1007/s10143-025-03829-y
- Citations
- 1
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Magyar Tudományos Akadémia
- Pécsi Tudományegyetem
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap
- National Research, Development and Innovation Office