Comparative cardiovascular risks of canagliflozin and selective SGLT2 inhibitors in type 2 diabetes

In this large real-world cohort, patients initiating canagliflozin had higher observed event rates for a composite of myocardial infarction, stroke, or all-cause mortality compared with those initiating selective SGLT2 inhibitors. These associations should be interpreted as exploratory and hypothesis-generating, given the observational design and differences from randomized trial evidence. Further research is needed to clarify potential differences among SGLT2 inhibitors in routine practice.