Perioperative leukocyte–plateletcrit shift as a prognostic signature in glioblastoma

Dynamic leukocyte-platelet coupling-especially Δ (post-op - pre-op) leu/PCT-provides independent prognostic information beyond standard covariates. CBC-based trajectories are low-cost and scalable and warrant prospective validation. Interpretation is limited by the absence of systematic MGMT methylation data and requires external validation and comparison with other prognostic scoring systems.