Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity
Juvenile hypoglycemia in GH insensitivity results from excessive insulin sensitivity, reduced glucose production, and impaired lipolysis. Normoglycemia in adulthood emerges through increased adiposity and moderated insulin sensitivity, independently of sex hormones. These findings elucidate the age-dependent metabolic adaptations in GH insensitivity.
Authors
- Martin Hrabě de Angelis (ORCID: https://orcid.org/0000-0002-7898-2353)
- Alexander Cecil (ORCID: https://orcid.org/0000-0002-1430-1790)
- Birgit Rathkolb (ORCID: https://orcid.org/0000-0003-1239-0547)
- Benedikt Mathias Kessler (ORCID: https://orcid.org/0000-0002-8160-2446)
- Cornelia Prehn (ORCID: https://orcid.org/0000-0002-1274-4715)
- Michael Roden (ORCID: https://orcid.org/0000-0001-8200-6382)
- SABINE KAHL (ORCID: https://orcid.org/0000-0003-3172-6050)
- Eckhard Wolf (ORCID: https://orcid.org/0000-0002-0430-9510)
- Elisabeth Kemter (ORCID: https://orcid.org/0000-0001-7785-7502)
- Kalliopi Pafili (ORCID: https://orcid.org/0000-0003-4293-3514)
- Sonja Kunz
- Simone Renner (ORCID: https://orcid.org/0000-0002-5866-4577)
- Gencer Sancar (ORCID: https://orcid.org/0000-0002-2098-0654)
- Silja Zettler
- John G. Jones (ORCID: https://orcid.org/0000-0002-3745-3885)
- Martin Bidlingmaier (ORCID: https://orcid.org/0000-0002-4681-6668)
- Arne Hinrichs (ORCID: https://orcid.org/0000-0003-3022-5983)
- Cristina Barosa (ORCID: https://orcid.org/0000-0001-7819-2434)
- Laeticia Laane (ORCID: https://orcid.org/0000-0002-7011-237X)
- J Szendroedi
- Judith Leonie Nono
- Malek Torgeman
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- Düsseldorf University Hospital (DE)
- Institute of Bioinformatics and Systems Biology (DE)
- Centre of Experimental Medicine of the Slovak Academy of Sciences (SK)
- Cell2B (Portugal) (PT)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-10-20
- DOI
- https://doi.org/10.1016/j.molmet.2025.102273
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00