A cross-sectional study clarifying the possible connection Between Irritable Bowel Syndrome and Serum Level of Vitamin D

Background and Aim:Irritable bowel syndrome (IBS) is among the most common chronic functional gastrointestinal disorders, affecting approximately 10%–22% of adults. Vitamin D has been linked to several systemic conditions; however, its exact role in IBS remains unclear. This study aimed to evaluate the possible association between serum vitamin D levels and IBS.Patients and Methods: A cross-sectional study was conducted on 100 participants divided into two groups: Group I included 50 patients diagnosed with IBS according to the Rome IV criteria. At the same time, Group II consisted of 50 healthy subjects serving as controls. Serum vitamin D levels were measured in both groups.Results: A statistically significant difference was observed between the two groups in terms of vitamin D levels (p-value = 0.012). Among IBS patients, 19 (38%) had sufficient vitamin D (>30 ng/mL), while 31 (62%) had subnormal levels. In contrast, 34 (68%) of the control group had sufficient levels, and 16 (32%) were deficient.Conclusions: Vitamin D deficiency may represent a contributing factor in IBS. Therefore, routine assessment of vitamin D levels could be beneficial in patients presenting with IBS.