Phytochemical and Antimicrobial Activities of Musa paradisiaca Peel Extracts against Multidrug-Resistant Bacteria from Post-Acne Skin Infections

Background The treatment of post-acne skin infections has been exacerbated by frequent evolvement of multi-drug resistant (MDR) pathogens. Objective, this study evaluated the phytochemical and antibacterial properties of (acetone, ethanol, methanol, and n-hexane) crude extracts of Musa paradisiac for their efficacy against selected MDR bacterial isolates from acne infection Methodology Bacterial isolates obtained from patients clinically diagnosed with acne vulgaris at three specialized hospitals in Najaf, Iraq, were analyzed and characterized using standard techniques. Among the multidrug-resistant isolates, three highly resistant bacterial isolates (Staphylococcus aureus and Pseudomonas aeruginosa) were selected for further evaluation. The susceptibility patterns of these isolates to crude extracts of Musa paradisiaca were evaluated. In addition, phytochemical properties of the extracts were determined to evaluate their antimicrobial potential. Results The results showed that Staphylococcus aureus is the dominant culprit in post-acne skin infections. The qualitative phytochemical analysis of the banana peel extract revealed the presence of diverse bioactive compounds, including alkaloids, flavonoids, tannins, glycosides, terpenoids, saponins, and phenols. The crude methanolic extract of banana peel showed superior broad-spectrum activity against multiple antibiotic-resistant bacterial isolates compared to the extracts (acetone, ethanol, and hexane). The concentration of 200 mg/ml was more effective than the concentrations of 100 and 50 mg/ml, indicating a potential bactericidal potential for post-acne skin infections. Conclusion Banana peels) Musa paradisiaca ( possess potent antimicrobial and phytochemical properties and are therefore recommended for the development of potential drugs to enhance therapeutic options against multidrug-resistant bacterial pathogens associated with acne vulgaris. However, further studies, including toxicity profiling and clinical validation, are recommended to confirm its safety and efficacy as a therapeutic alternative.